{"id":338555,"date":"2025-09-19T16:49:59","date_gmt":"2025-09-19T16:49:59","guid":{"rendered":"https:\/\/www.sentryair.com\/blog\/?p=338555"},"modified":"2025-09-19T17:28:40","modified_gmt":"2025-09-19T17:28:40","slug":"usp-797-guidelines-engineering-controls-for-compounding-allergenic-extracts","status":"publish","type":"post","link":"https:\/\/www.sentryair.com\/blog\/industry-news-standards\/usp-797-guidelines-engineering-controls-for-compounding-allergenic-extracts\/","title":{"rendered":"USP 797 Guidelines and Engineering Controls for Compounding Allergenic Extracts"},"content":{"rendered":"
\"Allergenic<\/a>

Allergy Practices must follow USP 797 when compounding or mixing allergenic extracts for individual patients.<\/p><\/div>\n

 
\nAllergy, ENT, and immunology practices must follow USP 797 when mixing patient-specific allergen extracts for subcutaneous immunotherapy (ACAAI 2023)<\/a>. Section 21 of USP 797 outlines the requirements for compounding allergen extracts to minimize the risk of contamination and ensure the patient\u2019s overall health is protected. USP 797 requirements apply to mixing allergen extracts for allergy testing and regular immunotherapy. Allergists used to be exempt from USP 797 guidelines but USP specifically wrote Section 21 for compounding allergen extracts which took effect November 1, 2023 (ACAAI 2023)<\/a>.<\/p>\n

What is USP 797 Section 21 the Allergy Exception?<\/b><\/h3>\n

USP 797 Section 21 outlines the safe practices for allergenic extract mixing to help protect patient safety. USP created a specific section for allergen extracts because mixing allergenic extracts varies greatly from regular compounding (ACAAI 2023)<\/a>. Section 21 details the requirements for personnel, garbing, facilities, cleaning, BUDs, labeling, transportation, and documentation. The purpose of USP 797 Section 21 is to help protect patient safety, help improve the sterility of extracts, and protect the reputation of allergists and ENT specialists (Fuel Medical 2023)<\/a>. The next section of this blog will briefly summarize the USP 797 Section 21 requirements.<\/p>\n

\n

USP 797 Section 21 Summary<\/h2>\n
\"USP<\/a>

Medical worker illustrating the proper way to garb for USP 797 (Taylor 2019)<\/a>.<\/p><\/div>\n

Personnel<\/u>
\nAllergy practices must designate an individual in charge of training other personnel in USP 797 practices. Personnel training must be completed, documented, and evaluated every 12 months. Personnel that have not compounded in the past 6 months must be reevaluated to ensure comprehension (ACAAI Appendix 5)<\/a>.<\/p>\n

Garbing<\/u>
\nProper garb must be low lint, fitted at the wrists and neck, and include head covers, masks, and sterile powder-free gloves. Personnel must rub their gloves with 70% IPA throughout compounding (ACAAI Appendix 5)<\/a>.<\/p>\n

Facilities<\/u>
\nMixing of allergenic extracts must be completed in a specified location called the allergenic extract compounding area (AECA) or in a primary engineering control (PEC) that meets ISO Class 5 cleanroom standards (ACAAI Appendix 5)<\/a>. This section will be explained in further detail in the next section<\/a>.<\/p>\n

Cleaning<\/u>
\nAll surfaces must be cleaned daily and after suspected contamination. The horizontal work surface must be cleaned in between each prescription set. 70% IPA is the recommended cleaner (ACAAI Appendix 5)<\/a>.<\/p>\n

BUDs<\/u>
\nThe beyond-use-date must be before the earliest expiration date of the allergenic extract and a maximum of 1 year after compounding (ACAAI Appendix 5)<\/a>.<\/p>\n

Labeling<\/u>
\nLabeling must include the patient\u2019s name, type of extract, dilution, BUD, and required storage information (ACAAI Appendix 5)<\/a>.<\/p>\n

Shipping<\/u>
\nTransportation must deliver vials in undamaged, sterile, and stable condition (ACAAI Appendix 5)<\/a>.<\/p>\n

Documentation<\/u>
\nThe designated in-charge personnel must keep all proper documentation including SOPs, training records, PEC certification reports, temperature logs, compounding records, adverse events, and investigations\/corrective actions (ACAAI Appendix 5)<\/a>.<\/p>\n

\n

<\/a><\/p>\n

USP 797 Allergenic Extracts Compounding Facility Requirements<\/h2>\n

Mixing or compounding of allergen extracts for individual patients must be conducted in an allergenic extract compounding area (AECA) or a primary engineering control (PEC) that meets ISO Class 5 such as a Laminar Airflow Workbench<\/b>. The American College of Allergy, Asthma & Immunology recommends implementing an AECA due to its simplicity; however, PECs offer greater protection and patient safety while offering a more sterile environment (ACAAI, 2023)<\/a>. Also, AECAs require extensive cleaning as all surfaces have to be sterilized including the walls, ceiling, floor, work surfaces, etc. PECs have a much smaller surface area, which allows for an easier cleanup. <\/p>\n

Laminar Airflow Workbenches Advantages<\/b><\/h3>\n

First, Laminar Airflow Workbenches help prevent contamination by supplying ISO Class 5 air to the workspace. To meet ISO Class 5 cleanroom standards, the filtered air within the hood must have less than 3,520 particles per cubic meter sized 0.5 microns (Farquharson 2023)<\/a>. Similarly, Laminar Airflow Workbenches provide a unidirectional airflow in a horizontal motion. This uniform, consistent airflow helps push particles out, improving cleanliness. Likewise, these systems offer a compact controlled space that takes up less room, ideal for smaller practices. Also, Laminar Airflow Workbenches are easier to clean than AECAs due to less surface area. <\/p>\n

\n

USP 797 Solutions for Allergy Clinics<\/h2>\n
\"USP<\/a>

USP 797-Certified Laminar Airflow Workbench offers a sterile workspace ideal for mixing allergy serums.<\/p><\/div>\n

Laminar Airflow Workbenches from Sentry Air provide a primary engineering control (PEC) that meets ISO Class 5 cleanroom standards. We specifically designed this hood to meet USP 797 for IV clinics; however, this system can also be used in allergy clinics. Laminar Airflow Workbenches offer a sterile workspace with a small footprint and easy installation. These hoods help reduce outside contamination by supplying HEPA-filtered air to the workspace. <\/p>\n

Benefits of the USP 797 Certified Laminar Airflow Workbench<\/b><\/h3>\n

\u2022 USP 797 certified
\n\u2022 ISO Class 5 cleanroom
\n\u2022 Horizontal unidirectional airflow
\n\u2022 Stringent in-house and 3rd party testing following CETA\u2019s CAG003 (the industry standard for certifying sterile compounding facilities)
\n\u2022 User-friendly control panel – adjustable LED light, fan speed control, and a Magnehelic gauge to monitor the filter\u2019s static pressure\/filter saturation.
\n\u2022 Small Footprint
\n\u2022 Supplies HEPA filtered air
\n\u2022 Made in the USA
\n\u2022 Backed by expert support
\n\u2022 Quick Lead Time \u2013 ships in 5 business days<\/p>\n

\"USP<\/a>

The USP 797-Certified Laminar Airflow Workbench includes an easy-to-use control panel with fan\/light controls, and a Magnehelic gauge to monitor the filter\u2019s saturation.<\/p><\/div>Filter:<\/b> HEPA (up to 99.97% efficiency on particles down to 0.3 microns) <\/p>\n

Dimensions (Depth x Width x Height):<\/b>
\nOuter: 25\u201d x 19.5\u201d x 21.75\u201d
\nInterior: 15.5\u201d x 17\u201d x 17\u201d
\nAccess Area: 17\u201d x 17\u201d<\/p>\n

Approximate Airflow:<\/b> up to 418 CFM with HEPA filter<\/p>\n

Light Intensity:<\/b> 1800 LUX at work surface<\/p>\n

\"Learn<\/a> \"Purchase<\/a>
\nDisclaimer: The information herein is provided solely as a customer service and for informational purposes only. No representation or warranty, express or implied, is made as to the accuracy or completeness of such information. Customers are solely responsible for independently verifying the accuracy and suitability of the information for their intended use.<\/i><\/p>\n

<\/div>\n
\n

Help improve medication safety for compounding allergenic extracts with USP 797 Certified Laminar Airflow Workbenches from Sentry Air. Contact us today!<\/h2>\n

\"Talk<\/a>  \"Email<\/a>  \"Visit<\/a><\/p>\n

\n

Related Blogs<\/h3>\n

\u2022 USP 797 Guidelines for IV Bag Preparation <\/a>
\n\u2022 Help Prevent PCR Contamination with Laminar Flow Hoods <\/a>
\n\u2022 Proper IV Bag and Medication Preparation Can Help Save Lives <\/a><\/p>\n

\n

References<\/h3>\n

<\/a>ACAAI. (October 2023). 2023 \u2013 USP 797 Implementation Nov. 1. American College of Allergy, Asthma, & Immunology.<\/i> Retrieved from: https:\/\/college.acaai.org\/2023-usp-797-implementation-nov-1\/<\/a>.<\/p>\n

<\/a>ACAAI. Appendix 5. USP Section 21 \u2013 Compounding Allergenic Extracts. American College of Allergy, Asthma, & Immunology.<\/i> Retrieved from: https:\/\/college.acaai.org\/wp-content\/uploads\/2021\/01\/Section-21-USP-Compounding-Allergenic-Extracts.pdf<\/a><\/p>\n

<\/a>Farquharson, G., Goldschmidt, N. (March\/April 2017). Understanding Cleanliness Classifications for Life Science Facilities. ISPE.<\/i> Retrieved from: https:\/\/ispe.org\/pharmaceutical-engineering\/march-april-2017\/understanding-cleanliness-classifications-life-science<\/a>.<\/p>\n

<\/a>Fuel Medical. (October 2023). Managing Your Allergy Department\u2019s Workflow with USP 797. Retrieved from: https:\/\/fuelmedical.com\/managing-your-allergy-departments-workflow-with-usp-797\/<\/a>.<\/p>\n

<\/a>Taylor, Daniel. (2019, Jan 20). USP 797: How to Garb. Accessed May 30, 2024. https:\/\/youtu.be\/u82S14pxF3I?si=o0iVJb_wZ9PxLSpm<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

  Allergy, ENT, and immunology practices must follow USP 797 when mixing patient-specific allergen extracts for subcutaneous immunotherapy (ACAAI 2023). Section 21 of USP 797 outlines the requirements for compounding allergen extracts to minimize the risk of contamination and ensure the patient\u2019s overall health is protected. USP 797 requirements apply to mixing allergen extracts for… Learn More<\/a><\/p>\n","protected":false},"author":2,"featured_media":338556,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[2839,1069],"tags":[2972,2969,2971,2968,2977,2976,2975,2973,2974,2970,2978,2941,2935],"class_list":["post-338555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news-standards","category-medical","tag-allergen","tag-allergen-extract-compounding","tag-allergenic","tag-allergenic-extracts","tag-allergists","tag-allergy-immunotherapy","tag-allergy-testing","tag-certification","tag-documentation","tag-ent-allergy","tag-iso-class-5","tag-portable-clean-room","tag-usp-797"],"yoast_head":"\nUSP 797 Guidelines & 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