The Israeli study deals with the effect of nano particles on human cardiovascular health.
The Canadian study addresses the effect of diesel fumes, which are also measured on the nano scale, on asthmatics and their DNA.
Not the first, probably not the last
They’re not the first to associate air pollution with cardiopulmonary disease. [We summarized several earlier studies here: Air pollution: It can hurt your heart.]
And unless the air we breathe is magically cleaned up overnight, it’s likely they won’t be the last.
Both discuss biological mechanisms that link airborne particles to ill health.
You should check these out. Perhaps one or both may get you up on your feet, insisting on clean air.
Nanoparticles and heart disease
They incubated macrophage cells, a type of white cell that is part of the immune system, with silicon dioxide nano particles.
They found that exposure to the silicon dioxide nanoparticles increased the macrophage cells’ production of substances associated with atherosclerosis, including triglycerides.
Triglycerides are a type of fat in the blood. Too much in the bloodstream contributes to atherosclerosis, or hardening of the arteries.
Follow the links below for more information.
Title: Silicon dioxide nanoparticles increase macrophage atherogenicity: Stimulation of cellular cytotoxicity, oxidative stress, and triglycerides accumulation
Authors: Lauren Petrick, Mira Rosenblat, Nicole Paland, Michael Aviram
Journal: Environmental Toxicology, November 2014
Link to abstract (full study behind paywall):
Diesel exhaust and asthmatics
DNA methylation is a mechanism that affects gene expression.
It takes place at specific genome sites and is essential to gene activity.
For this study, real people breathed real diesel fumes.
Analysis indicated that airborne particulate matter could have an impact on the participants’ gene expression due to its impact on DNA methylation.
The study suggests that particulate may be an external prompt that changes how a cell reads genes, without actually changing the DNA sequence.
Title: Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics
Authors: Ruiwei Jiang, Meaghan J Jones, Francesco Sava, Michael S. Kobor, Christopher Carlsten
Journal: Particle and Fibre Technology, November 2014
Link to paper (open access):
The big harm
Harm to your respiratory system doesn’t have to be big and obvious. In fact, it may take small, repeated harms that create the big harm that lays you low.
So develop ventilation strategies that protect your lungs today. You deserve it.
For additional support, here’s a link to some blogs we written on fine particulate.
We provide workplace ventilation solutions
Our Application Specialists have expertise in a variety of industrial and professional applications that require respiratory protection and strategies.
When customers provide testimony on the impact of our products on their business and the welfare of their workers, they also mention our quality customer service.